Non-metastatic childhood ependymomas

摘要: Abstract Purpose: Intracranial ependymomas of childhood are relatively infrequent. There significant disagreements concerning optimal postoperative treatment as well the patterns relapse following treatment. The purpose this retrospective study was analysis recurrence pattern and therefore implication on extent radiotherapy fields. Data from 37 patients refereed within 19 years were used for study. Patients methods: From April 1975 to July 1993, children aged 1–14 referred an intracranial ependymoma. Twenty-eight received radiation therapy 26 chemotherapy. median follow-up is 6 (range 2 months years). Results: Overall survival event free at 5 10 40%. Eighteen relapsed. Relapses occurred 1.5 3.6 post distant in four cases local 14. Age, sex, primary resection, chemotherapy type did not influence outcome. Children with poorly differentiated tumors who receive post-operative had a higher rate but difference statistically significant. Conclusions: Despite doses ≥ 50 Gy majority recurrences local. Our results, despite small number accordance those previously published, suggest that prophylactic craniospinal irradiation superfluous. Better means achieved control required, such three-dimensional conformal dose-escalation or hyperfractionation regimen.