9.7 Molecular Modeling and Simulations of Transporter Proteins – The Transmembrane Allosteric Machinery
作者： L. Shi
DOI: 10.1016/B978-0-12-374920-8.00910-3
关键词: Context (language use) 、 Transmembrane protein 、 ATP-binding cassette transporter 、 Transporter 、 Biochemistry 、 Transport protein 、 Biology 、 Molecular model 、 Symporter 、 Neurotransmitter sodium symporter
摘要: This chapter covers topics of molecular modeling and simulations for transporter proteins, with a focus on the neurotransmitter:sodium symporter (NSS) family in context relevant work other families, example, ABC transporters glutamate transporters. Three major aspects computational studies structure-function relationships are reviewed: i) sequence structure analysis, ii) building models simulation systems, iii) carrying out mechanistic studies. The review is concluded proposal novel transport model based findings NSS family.
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