Allogeneic bone marrow-derived flk-1+Sca-1- mesenchymal stem cells leads to stable mixed chimerism and donor-specific tolerance.
作者： Weimin Deng , Qin Han , Lianming Liao , Changhong Li , Wei Ge
DOI: 10.1016/J.EXPHEM.2004.06.009
关键词: Mixed lymphocyte reaction 、 Haematopoiesis 、 Mesenchymal stem cell 、 Transplantation 、 Transplantation Chimera 、 Immune tolerance 、 Bone marrow 、 Biology 、 Antigen 、 Immunology
摘要: Objective To investigate the possibility of flk-1 + Sca-1 − bone marrow–derived mesenchymal stem cells (bMSCs) to induce stable mixed chimerism and donor-specific graft tolerance. Methods Allogeneic bMSCs syngeneic marrow (BM) were cotransplanted into lethally irradiated (8.5 Gy) recipient mice. FACS was used analyze 150 days later. Donor-type skin transplantation performed observe immunotolerance in Mixed lymphocyte reaction (MLR) mitogen proliferative assays evaluate response splenocytes from Results More than 5% donor-derived CD3 detected Long-term survival donor-type grafts observed. MLR showed that mice had low immunoresponse donor but retained normal ConA-induced compared with Conclusion Our results show for first time induction hematopoietic can be achieved allogeneic bMSC transplantation, which leads permanent host long-term acceptance.
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