Evaluating the role of public health in implementation of genomics-related recommendations: a case study of hereditary cancers using the CDC Science Impact Framework

摘要: Public health plays an important role in ensuring access to interventions that can prevent disease, including the implementation of evidence-based genomic recommendations. We used Centers for Disease Control and Prevention (CDC) Science Impact Framework trace impact public activities partnerships on 2009 Evaluation Genomic Applications Practice (EGAPP) Lynch Syndrome screening recommendation 2005 2013 United States Preventive Services Task Force (USPSTF) BRCA1 BRCA2 testing The EGAPP USPSTF recommendations have each been cited by >300 peer-reviewed publications. CDC funds selected states build capacity integrate these into programs, through education, policy, surveillance, partnerships. Most state cancer control plans include genomics-related goals, objectives, or strategies. Since recommendation, major private payers now provide coverage all newly diagnosed colorectal cancers. National guidelines initiatives, Healthy People 2020, included similar However, disparities based race, ethnicity, rural residence remain challenges. achievements promoting use genomics prevention hereditary cancers inform future applications health.