Squeezing hydrogels for controlled oral drug delivery
作者： Anna Gutowska , Jong Seok Bark , Ick Chan Kwon , You Han Bae , Younsik Cha
DOI: 10.1016/S0168-3659(97)00041-2
关键词: Liberation 、 Cationic polymerization 、 Chemical engineering 、 Phase (matter) 、 Dosage form 、 Delayed release (linguistics) 、 Kinetics 、 Stereochemistry 、 Chemistry 、 Self-healing hydrogels 、 Swelling
摘要: Abstract A new delivery device based on a novel, squeezing hydrogel concept, utilizing specific swelling-deswelling characteristics of temperature-, temperature/pH- and pH-sensitive hydrogels is described. These have been designed to exhibit controlled kinetics, hence, variety release profiles may be generated including: delayed, zero-order or on-off profiles. temperature sensitive NiPAAm/AAc demonstrated `on-off' profile in response change between 35° 40°C with the `on' phase at higher temperature. Drug from pH/T NiPAAm/BMA/DEAEMA were strongly affected by pH 37°C. The gel minimal delayed 2.0 7.4 mechanical mechanism that was determined deswelling kinetics. also obtained for cationic 7.4. For all studied systems, it concluded composition an applied stimuli (T, pH, pH/T), swelling/deswelling kinetics
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