Delivering a STINGing Blow to Small Cell Lung Cancer via Synergistic Inhibition of DNA-Damage Response and Immune-Checkpoint Pathways.

Adi F. Gazdar, Paul A. Bunn, John D. Minna, Small-cell lung cancer: what we know, what we need to know and the path forward Nature Reviews Cancer. ,vol. 17, pp. 725- 737 ,(2017) , 10.1038/NRC.2017.87

Triparna Sen, Carl M. Gay, Lauren Averett Byers, Targeting DNA damage repair in small cell lung cancer and the biomarker landscape. Translational lung cancer research. ,vol. 7, pp. 50- 68 ,(2018) , 10.21037/TLCR.2018.02.03

Jianfeng Shen, Wei Zhao, Zhenlin Ju, Lulu Wang, Yang Peng, Marilyne Labrie, Timothy A. Yap, Gordon B. Mills, Guang Peng, PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness Cancer Research. ,vol. 79, pp. 311- 319 ,(2019) , 10.1158/0008-5472.CAN-18-1003

Wanqiang Sheng, Martin W. LaFleur, Thao H. Nguyen, Sujun Chen, Ankur Chakravarthy, Jake Ryan Conway, Ying Li, Hao Chen, Henry Yang, Pang-Hung Hsu, Eliezer M. Van Allen, Gordon J. Freeman, Daniel D. De Carvalho, Housheng Hansen He, Arlene H. Sharpe, Yang Shi, LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade Cell. ,vol. 174, pp. 549- 563 ,(2018) , 10.1016/J.CELL.2018.05.052

Leora Horn, Aaron S Mansfield, Aleksandra Szczęsna, Libor Havel, Maciej Krzakowski, Maximilian J Hochmair, Florian Huemer, György Losonczy, Melissa L Johnson, Makoto Nishio, Martin Reck, Tony Mok, Sivuonthanh Lam, David S Shames, Juan Liu, Beiying Ding, Ariel Lopez-Chavez, Fairooz Kabbinavar, Wei Lin, Alan Sandler, Stephen V Liu, None, First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer The New England Journal of Medicine. ,vol. 379, pp. 2220- 2229 ,(2018) , 10.1056/NEJMOA1809064

Liya Ding, Hye-Jung Kim, Qiwei Wang, Michael Kearns, Tao Jiang, Carolynn E. Ohlson, Ben B. Li, Shaozhen Xie, Joyce F. Liu, Elizabeth H. Stover, Brooke E. Howitt, Roderick T. Bronson, Suzan Lazo, Thomas M. Roberts, Gordon J. Freeman, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Jean J. Zhao, PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Reports. ,vol. 25, pp. 2972- ,(2018) , 10.1016/J.CELREP.2018.11.054

Jeffrey J. Ishizuka, Robert T. Manguso, Collins K. Cheruiyot, Kevin Bi, Arpit Panda, Arvin Iracheta-Vellve, Brian C. Miller, Peter P. Du, Kathleen B. Yates, Juan Dubrot, Ilana Buchumenski, Dawn E. Comstock, Flavian D. Brown, Austin Ayer, Ian C. Kohnle, Hans W. Pope, Margaret D. Zimmer, Debattama R. Sen, Sarah K. Lane-Reticker, Emily J. Robitschek, Gabriel K. Griffin, Natalie B. Collins, Adrienne H. Long, John G. Doench, David Kozono, Erez Y. Levanon, W. Nicholas Haining, Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade Nature. ,vol. 565, pp. 43- 48 ,(2019) , 10.1038/S41586-018-0768-9

Roman M. Chabanon, Gareth Muirhead, Dragomir B. Krastev, Julien Adam, Daphné Morel, Marlène Garrido, Andrew Lamb, Clémence Hénon, Nicolas Dorvault, Mathieu Rouanne, Rebecca Marlow, Ilirjana Bajrami, Marta Llorca Cardeñosa, Asha Konde, Benjamin Besse, Alan Ashworth, Stephen J. Pettitt, Syed Haider, Aurélien Marabelle, Andrew N.J. Tutt, Jean-Charles Soria, Christopher J. Lord, Sophie Postel-Vinay, PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer Journal of Clinical Investigation. ,vol. 129, pp. 1211- 1228 ,(2019) , 10.1172/JCI123319

Arnaud Augert, Emily Eastwood, Ali H. Ibrahim, Nan Wu, Eli Grunblatt, Ryan Basom, Denny Liggitt, Keith D. Eaton, Renato Martins, John T. Poirier, Charles M. Rudin, Francesca Milletti, Wei-Yi Cheng, Fiona Mack, David MacPherson, Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition Science Signaling. ,vol. 12, ,(2019) , 10.1126/SCISIGNAL.AAU2922

Triparna Sen, B Leticia Rodriguez, Limo Chen, Carminia M Della Corte, Naoto Morikawa, Junya Fujimoto, Sandra Cristea, Thuyen Nguyen, Lixia Diao, Lerong Li, Youhong Fan, Yongbin Yang, Jing Wang, Bonnie S Glisson, Ignacio I Wistuba, Julien Sage, John V Heymach, Don L Gibbons, Lauren A Byers, None, Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer Cancer Discovery. ,vol. 9, pp. 646- 661 ,(2019) , 10.1158/2159-8290.CD-18-1020