Erratum to: Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice.
作者： Marius Heitzer , Sarah Kaiser , Mithila Kanagaratnam , Adib Zendedel , Philipp Hartmann
DOI: 10.1007/S12035-017-0391-Z
关键词: Amyotrophic lateral sclerosis 、 Caspase 1 、 Immunology 、 Inflammasome 、 Spinal cord 、 Neuroprotection 、 Neuroinflammation 、 Endocrinology 、 Lumbar Spinal Cord 、 Internal medicine 、 SOD1 、 Medicine
摘要: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism ALS complex not yet fully understood. Neuroinflammation believed to significantly contribute progression. Inflammasome activation was recently shown in spinal cord human sporadic patients SOD1(G93A) mouse model for ALS. In present study, we investigated neuroprotective anti-inflammatory effects 17β-estradiol (E2) treatment pre-symptomatic symptomatic male mice. Symptomatic mice with E2 substitution exhibited improved motor performance correlating an increased survival motoneurons lumbar cord. Expression NLRP3 inflammasome proteins levels activated caspase 1 mature interleukin beta were reduced supplemented E2.
springer.com
paperity.org参考文章(101)
Hristelina Ilieva, Magdalini Polymenidou, Don W. Cleveland, Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond Journal of Cell Biology. ,vol. 187, pp. 761- 772 ,(2009) , 10.1083/JCB.200908164
James L. Young, Galina K. Sukhova, Don Foster, Walter Kisiel, Peter Libby, Uwe Schönbeck, The Serpin Proteinase Inhibitor 9 Is an Endogenous Inhibitor of Interleukin 1β–Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells Journal of Experimental Medicine. ,vol. 191, pp. 1535- 1544 ,(2000) , 10.1084/JEM.191.9.1535
Hazim Kadhim, Paul Deltenre, Jean-Jacques Martin, Guillaume Sébire, In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms. Medical Hypotheses. ,vol. 86, pp. 14- 17 ,(2016) , 10.1016/J.MEHY.2015.11.022
Markus Kipp, Tanja Hochstrasser, Christoph Schmitz, Cordian Beyer, Female sex steroids and glia cells: Impact on multiple sclerosis lesion formation and fine tuning of the local neurodegenerative cellular network. Neuroscience & Biobehavioral Reviews. ,vol. 67, pp. 125- 136 ,(2016) , 10.1016/J.NEUBIOREV.2015.11.016
J. D. Small, H. L. Foster, J. G. Fox, The mouse in biomedical research. Volume III. Normative biology, immunology, and husbandry. Academic Press. ,(1983)
Hui Sheng, Qingyue Bao, Yujun Wang, Jianqiang Lu, Xin Ni, Yongjun Xu, NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain Behavior and Immunity. ,vol. 56, pp. 175- 186 ,(2016) , 10.1016/J.BBI.2016.02.022
Tian‐Zhi Zhao, Qian Ding, Jun Hu, Shi‐Ming He, Fei Shi, Lian‐Ting Ma, GPER expressed on microglia mediates the anti‐inflammatory effect of estradiol in ischemic stroke Brain and behavior. ,vol. 6, ,(2016) , 10.1002/BRB3.449
Mathieu Gravel, Louis-Charles Béland, Geneviève Soucy, Essam Abdelhamid, Reza Rahimian, Claude Gravel, Jasna Kriz, IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1 The Journal of Neuroscience. ,vol. 36, pp. 1031- 1048 ,(2016) , 10.1523/JNEUROSCI.0854-15.2016
Yuriko Kitajima, Yusuke Ono, Estrogens maintain skeletal muscle and satellite cell functions Journal of Endocrinology. ,vol. 229, pp. 267- 275 ,(2016) , 10.1530/JOE-15-0476
G. Gargiulo-Monachelli, M. Sivori, M. Meyer, R. Sica, A. De Nicola, M. Gonzalez-Deniselle, Circulating gonadal and adrenal steroids in amyotrophic lateral sclerosis: possible markers of susceptibility and outcome. Hormone and Metabolic Research. ,vol. 46, pp. 433- 439 ,(2014) , 10.1055/S-0034-1371891