Changes in diastolic time with various pharmacologic agents: implication for myocardial perfusion.
作者： H Boudoulas , S E Rittgers , R P Lewis , C V Leier , A M Weissler
关键词: Left ventricular hypertrophy 、 Systole 、 Heart rate 、 Propranolol 、 Diastole 、 Internal medicine 、 Dobutamine 、 Cardiology 、 Bolus (medicine) 、 Perfusion 、 Medicine
摘要: Diastolic time (DT) is calculated as the cycle length (RR) minus electromechanical systole (QS2). The ratio of DT (RR-QS2) to RR interval times 100, or percent diastole (%D), varies nonlinearly with heart rate (HR), increasing rapidly decreasing HR. effect commonly used cardioactive agents on %D was studied in five groups normal subjects. In group 1 (n = 12), propranolol (160 mg daily) increased from 55.9 +/- 1.7 64.7 1.3 (p less than 0.001) by slowing 2 dobutamine (2.5 micrograms/kg/min) 56.4 1.4 61.8 0.005) shortening QS2. 3 10), Cedilanid-D (1.6 i.v.) 55.5 63.2 0.7 0.001), both HR and 4 isoproterenol (2 micrograms/min) shortened QS2 significantly. net result a significant reduction 56.1 53.5 1.1, 0.05). 5 15), 100-mg bolus i.v. lidocaine did not have %D. This study indicates that cardiovascular drugs may effects relative duration either affecting systole. clinical implications for patients coronary artery disease left ventricular hypertrophy, since cases flow mostly diastolic.
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