Comparative Genomics of Multidrug Resistance in Acinetobacter baumannii

摘要: Acinetobacter baumannii is a species of nonfermentative gram-negative bacteria commonly found in water and soil. This organism was susceptible to most antibiotics the 1970s. It has now become major cause hospital-acquired infections worldwide due its remarkable propensity rapidly acquire resistance determinants wide range antibacterial agents. Here we use comparative genomic approach identify complete repertoire genes exhibited by multidrug-resistant A. strain AYE, which epidemic France, as well investigate mechanisms their acquisition comparison with fully SDF, associated human body lice. The assembly whole shotgun genome sequences strains AYE SDF gave an estimated size 3.9 3.2 Mb, respectively. exhibits 86-kb region termed island—the largest identified date—in 45 are clustered. At homologous location, 20 kb-genomic island flanked transposases but devoid markers. Such switching structure might be hotspot that could explain rapid markers under antimicrobial pressure. Sequence similarity phylogenetic analyses confirm have been recently acquired from genera Pseudomonas, Salmonella, or Escherichia. study also resulted discovery 19 new putative genes. Whole-genome sequencing appears fast efficient exhaustive identification infectious agents clinical significance.