Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear.

摘要: Revealing the mechanisms underlying reversible physiology of hibernation could have applications to both human and animal health as is often associated with disease-like states. The present study uses RNA-sequencing reveal tissue seasonal transcriptional changes occurring in grizzly bears (Ursus arctos horribilis). Comparing other seasons, bear adipose has a greater number differentially expressed genes than liver skeletal muscle. During hyperphagia, more 900 compared active season. Hibernation characterized by reduced expression insulin signaling, muscle protein degradation, urea production, increased within anabolic pathways. Across all three tissues we find subset shared genes, some which are uncharacterized, that together may reflect common regulatory mechanism. identified gene families be useful for developing novel therapeutics treat diseases.