PTEN and PIK3CA gene copy numbers and poor outcomes in non-small cell lung cancer patients with gefitinib therapy

作者: M J Fidler , L E Morrison , S Basu , L Buckingham , K Walters

DOI: 10.1038/BJC.2011.494

关键词: MedicineLung cancerPTENPIK3CA geneCancer researchSurvival analysisNon small cellRetrospective cohort studyGefitinibGene dosage

摘要: PTEN and PIK3CA gene copy numbers poor outcomes in non-small cell lung cancer patients with gefitinib therapy

参考文章(26)
Ming-Sound Tsao, Akira Sakurada, Jean-Claude Cutz, Chang-Qi Zhu, Suzanne Kamel-Reid, Jeremy Squire, Ian Lorimer, Tong Zhang, Ni Liu, Manijeh Daneshmand, Paula Marrano, Gilda da Cunha Santos, Alain Lagarde, Frank Richardson, Lesley Seymour, Marlo Whitehead, Keyue Ding, Joseph Pater, Frances A. Shepherd, Erlotinib in lung cancer - molecular and clinical predictors of outcome. The New England Journal of Medicine. ,vol. 353, pp. 133- 144 ,(2005) , 10.1056/NEJMOA050736
Jeffrey A. Engelman, Targeting PI3K signalling in cancer: opportunities, challenges and limitations Nature Reviews Cancer. ,vol. 9, pp. 550- 562 ,(2009) , 10.1038/NRC2664
Roberto Bianco, Incheol Shin, Christoph A Ritter, F Michael Yakes, Andrea Basso, Neal Rosen, Junji Tsurutani, Phillip A Dennis, Gordon B Mills, Carlos L Arteaga, Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors Oncogene. ,vol. 22, pp. 2812- 2822 ,(2003) , 10.1038/SJ.ONC.1206388
Federico Cappuzzo, Fred R. Hirsch, Elisa Rossi, Stefania Bartolini, Giovanni L. Ceresoli, Lynne Bemis, Jerry Haney, Samir Witta, Kathleen Danenberg, Irene Domenichini, Vienna Ludovini, Elisabetta Magrini, Vanesa Gregorc, Claudio Doglioni, Angelo Sidoni, Maurizio Tonato, Wilbur A. Franklin, Lucio Crino, Paul A. Bunn, Marileila Varella-Garcia, Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer Journal of the National Cancer Institute. ,vol. 97, pp. 643- 655 ,(2005) , 10.1093/JNCI/DJI112
T Fujita, H Doihara, K Kawasaki, D Takabatake, H Takahashi, K Washio, K Tsukuda, Y Ogasawara, N Shimizu, PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer British Journal of Cancer. ,vol. 94, pp. 247- 252 ,(2006) , 10.1038/SJ.BJC.6602926
Lela E. Buckingham, John S. Coon, Larry E. Morrison, Kristine K.B. Jacobson, Susan S. Jewell, Kelly A. Kaiser, Ann M. Mauer, Tariq Muzzafar, Clayton Polowy, Sanjib Basu, Meryl Gale, Victoria M. Villaflor, Philip Bonomi, The Prognostic Value of Chromosome 7 Polysomy in Non-small Cell Lung Cancer Patients Treated with Gefitinib Journal of Thoracic Oncology. ,vol. 2, pp. 414- 422 ,(2007) , 10.1097/01.JTO.0000268675.02744.B0
Raffaella Sordella, Daphne W Bell, Daniel A Haber, Jeffrey Settleman, Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways Science. ,vol. 305, pp. 1163- 1167 ,(2004) , 10.1126/SCIENCE.1101637
Katrien Berns, Hugo M. Horlings, Bryan T. Hennessy, Mandy Madiredjo, E. Marielle Hijmans, Karin Beelen, Sabine C. Linn, Ana Maria Gonzalez-Angulo, Katherine Stemke-Hale, Michael Hauptmann, Roderick L. Beijersbergen, Gordon B. Mills, Marc J. van de Vijver, René Bernards, A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. ,vol. 12, pp. 395- 402 ,(2007) , 10.1016/J.CCR.2007.08.030
J. A. Engelman, P. A. Janne, C. Mermel, J. Pearlberg, T. Mukohara, C. Fleet, K. Cichowski, B. E. Johnson, L. C. Cantley, ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 3788- 3793 ,(2005) , 10.1073/PNAS.0409773102
L. C. Cantley, The Phosphoinositide 3-Kinase Pathway Science. ,vol. 296, pp. 1655- 1657 ,(2002) , 10.1126/SCIENCE.296.5573.1655