Nab-paclitaxel efficacy in the orthotopic model of human breast cancer is significantly enhanced by concurrent anti-vascular endothelial growth factor A therapy.

作者: Lisa D. Volk , Michael J. Flister , Christopher M. Bivens , Alan Stutzman , Neil Desai

DOI: 10.1593/NEO.08302

关键词: Clonogenic assayCancer researchMetastasisCancerMedicinePathologyBevacizumabGrowth factorLymph nodeVascular endothelial growth factor APaclitaxel

摘要: … paclitaxel toxicity on cultured tumor cells. Antitumor effects were assessed in mice with luciferase-tagged, wellestablished MDA-MB-231 … of 231-Luc+ cells treated with nab-paclitaxel (…

参考文章(64)
W. Liu, S. A. Ahmad, N. Reinmuth, R. M. Shaheen, Y. D. Jung, F. Fan, L. M. Ellis, Endothelial cell survival and apoptosis in the tumor vasculature. Apoptosis. ,vol. 5, pp. 323- 328 ,(2000) , 10.1023/A:1009679307513
Beverly A. Teicher, Krishna Menon, Enrique Alvarez, Chuan Shih, Margaret M. Faul, Antiangiogenic and Antitumor Effects of a Protein Kinase Cβ Inhibitor in Human Breast Cancer and Ovarian Cancer Xenografts Investigational New Drugs. ,vol. 20, pp. 241- 251 ,(2002) , 10.1023/A:1016297611825
Michael I. Koukourakis, Alexandros Polychronidis, Sotirios Botaitis, Constantinos Simopoulos, Alexandra Giatromanolaki, Efthimios Sivridis, Sebach Perente, The effect of trastuzumab/docatexel combination on breast cancer angiogenesis: dichotomus effect predictable by the HIFI alpha/VEGF pre-treatment status? Anticancer Research. ,vol. 23, pp. 1673- 1680 ,(2003)
Keith J. Luzzi, Ian C. MacDonald, Eric E. Schmidt, Nancy Kerkvliet, Vincent L. Morris, Ann F. Chambers, Alan C. Groom, Multistep Nature of Metastatic Inefficiency The American Journal of Pathology. ,vol. 153, pp. 865- 873 ,(1998) , 10.1016/S0002-9440(10)65628-3
Bruno Damascelli, Giulio Cant�, Franco Mattavelli, Paolo Tamplenizza, Paolo Bidoli, Ermanno Leo, Franco Dosio, Anna M. Cerrotta, Giuseppe Di Tolla, Laura F. Frigerio, Francesco Garbagnati, Rodolfo Lanocita, Alfonso Marchian�, Gianluigi Patelli, Carlo Spreafico, Vladimira Tich�, Valentina Vespro, Franco Zunino, Intraarterial chemotherapy with polyoxyethylated castor oil free paclitaxel, incorporated in albumin nanoparticles (ABI-007): Phase I study of patients with squamous cell carcinoma of the head and neck and anal canal: preliminary evidence of clinical activity. Cancer. ,vol. 92, pp. 2592- 2602 ,(2001) , 10.1002/1097-0142(20011115)92:10<2592::AID-CNCR1612>3.0.CO;2-4
Arthur M. Mercurio, Robin E. Bachelder, Melissa A. Wendt, Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Research. ,vol. 62, pp. 7203- 7206 ,(2002)
David J. McConkey, Daniel J. Hicklin, Darren W. Davis, Keiji Inoue, Colin P.N. Dinney, Robert Radinsky, Takashi Karashima, Joel W. Slaton, Treatment of Human Metastatic Transitional Cell Carcinoma of the Bladder in a Murine Model with the Anti-Vascular Endothelial Growth Factor Receptor Monoclonal Antibody DC101 and Paclitaxel Clinical Cancer Research. ,vol. 6, pp. 2635- 2643 ,(2000)
Brandt Whitehurst, Michael J. Flister, Juhi Bagaitkar, Lisa Volk, Christopher M. Bivens, Brent Pickett, Emely Castro-Rivera, Rolf A. Brekken, Robert D. Gerard, Sophia Ran, Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model International Journal of Cancer. ,vol. 121, pp. 2181- 2191 ,(2007) , 10.1002/IJC.22937
Makoto Sumitomo, Tomohiko Asano, Junichi Asakuma, Takako Asano, Akio Horiguchi, Masamichi Hayakawa, ZD1839 Modulates Paclitaxel Response in Renal Cancer by Blocking Paclitaxel-Induced Activation of the Epidermal Growth Factor Receptor–Extracellular Signal-Regulated Kinase Pathway Clinical Cancer Research. ,vol. 10, pp. 794- 801 ,(2004) , 10.1158/1078-0432.CCR-0948-03