The Role of Reactive Oxygen Species in Integrin and Matrix Metalloproteinase Expression and Function

作者: Gunbjørg Svineng , Chandra Ravuri , Oddveig Rikardsen , Nils-Erik Huseby , Jan-Olof Winberg

DOI: 10.1080/03008200802143166

关键词: Cell migrationExtracellular matrixIntegrinMatrix metalloproteinaseBiologySignal transductionFibronectinIntegrin bindingCell adhesionCell biology

摘要: Cell adhesion and migration is largely dependent on integrin binding to extracellular matrix, several signalling pathways involved in these processes have been shown be modified by reactive oxygen species (ROS). In fact, activation linked increased ROS production NADPH-oxidases, 5-lipoxygenase, release from mitochondria. intimately degradation of the activated matrix metalloproteinases (MMPs) are a prerequisite for cancer cell invasion metastasis. this minireview, we focus interplay between integrin-mediated MMP expression as well its biological pathobiological significance.

参考文章(64)
Jukka Westermarck, Veli‐Matti Kähäri, Regulation of matrix metalloproteinase expression in tumor invasion The FASEB Journal. ,vol. 13, pp. 781- 792 ,(1999) , 10.1096/FASEBJ.13.8.781
Paola Chiarugi, Francesca Buricchi, Protein Tyrosine Phosphorylation and Reversible Oxidation: Two Cross-Talking Posttranslation Modifications Antioxidants & Redox Signaling. ,vol. 9, pp. 1- 24 ,(2007) , 10.1089/ARS.2007.9.1
Partha Roy, Sandip K. Roy, Ashoke Mitra, Arun P. Kulkarni, Superoxide generation by lipoxygenase in the presence of NADH and NADPH Biochimica et Biophysica Acta. ,vol. 1214, pp. 171- 179 ,(1994) , 10.1016/0005-2760(94)90041-8
Chunhong Yan, Douglas D. Boyd, Regulation of matrix metalloproteinase gene expression. Journal of Cellular Physiology. ,vol. 211, pp. 19- 26 ,(2007) , 10.1002/JCP.20948
Sue Goo Rhee, Sang Won Kang, Woojin Jeong, Tong-Shin Chang, Kap-Seok Yang, Hyun Ae Woo, Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins Current Opinion in Cell Biology. ,vol. 17, pp. 183- 189 ,(2005) , 10.1016/J.CEB.2005.02.004
Allison L. Berrier, Kenneth M. Yamada, Cell–matrix adhesion Journal of Cellular Physiology. ,vol. 213, pp. 565- 573 ,(2007) , 10.1002/JCP.21237
Wen-Sheng Wu, The signaling mechanism of ROS in tumor progression Cancer and Metastasis Reviews. ,vol. 25, pp. 695- 705 ,(2007) , 10.1007/S10555-006-9037-8
Armelle A Troussard, Penny Costello, T Nathan Yoganathan, Shigehiro Kumagai, Calvin D Roskelley, Shoukat Dedhar, The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene. ,vol. 19, pp. 5444- 5452 ,(2000) , 10.1038/SJ.ONC.1203928