Abstract #LB-169: DNA methylation profiling reveals a field defect in bladders with cancer and a distinct hypomethylated pattern in non-invasive bladder tumors

摘要: AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO Transitional cell carcinoma (TCC) is the most common form of bladder cancer in United States. The disease characterized by a high rate recurrence and necessitates frequent invasive monitoring. biological basis for remains unknown, although presence field defect has been postulated. DNA methylation shown to be involved defects other cancers. Therefore, we decided profile changes that occur during on large scale. Using Illumina GoldenGate assay measured urothelium samples from three different sources: 12 age-matched cancer-free patients, 52 non-invasive tumors, 39 tumors their corresponding normal tissues. A comparison TCC tissue versus patients yielded 158 hypermethylated loci 356 hypomethylated TCC. Furthermore, also found 21 were not only but adjacent appearing when compared indicating an epigenetic patients. These may provide markers identification individuals at risk developing cancer, as they are methylated bladders with cancer. In addition, distinct pattern hypomethylation tumors. Two molecular pathways have suggested development papillary rarely p53 mutations, while cancers commonly mutations. unique suggest there between Taken together our data reveals Therefore aberrant provides predict detect after resection. Citation Information: In: Proc Am Assoc Cancer Res; 2009 18-22; CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-169.