Biomarkers in Trypanosoma cruzi-Infected and Uninfected Individuals with Varying Severity of Cardiomyopathy in Santa Cruz, Bolivia

摘要: Background: Twenty to thirty percent of persons with Trypanosoma cruzi infection eventually develop cardiomyopathy. If an early indicator were be identified and validated in longitudinal studies, this could enable treatment prioritized for those at highest risk. We evaluated cardiac extracellular matrix remodeling markers across stages T. infected (Tc+) uninfected (Tc2) individuals. Methods: Participants recruited a public hospital Santa Cruz, Bolivia assigned severity by electrocardiogram echocardiogram. BNP, NTproBNP, CKMB, troponin I, MMP-2, MMP-9, TIMP-1, TIMP-2, TGFb1, TGFb2 measured specimens from 265 individuals using multiplex bead systems. Biomarker levels compared between Tc+ Tc2 groups, stages. Receivers operating characteristic (ROC) curves created; area under curve.0.60, logistic regression was performed. Results: Analyses stratified stage showed no significant differences biomarker Tc status. Among individuals, insufficiency had higher TIMP-2 than normal ejection fraction left ventricular diameter. No individual marker distinguished the two earliest stages, but ROC-based analyses, MMP-2/MMP-9 ratio significantly without ECG abnormalities. Conclusions: rose increasing did not distinguish Chagas cardiomyopathy other cardiomyopathies. insufficiency, only differed changes.