Deterioration of Left Ventricular Chamber Performance After Bed Rest “Cardiovascular Deconditioning” or Hypovolemia?
作者： Merja A. Perhonen , Julie H. Zuckerman , Benjamin D. Levine
DOI: 10.1161/01.CIR.103.14.1851
关键词: Medicine 、 Anesthesia 、 Blood volume 、 Hypovolemia 、 Bed rest 、 Hemodynamics 、 Cardiovascular Deconditioning 、 Stroke volume 、 Diastole 、 Pulmonary wedge pressure
摘要: Background—Orthostatic intolerance after bed rest is characterized by hypovolemia and an excessive reduction in stroke volume (SV) the upright position. We studied whether SV due to a specific adaptation of heart head-down tilt (HDTBR) or acute alone. Methods Results—We constructed left ventricular (LV) pressure-volume curves from pulmonary capillary wedge pressure LV end-diastolic Starling during lower body negative saline loading 7 men (25±2 years) before 2 weeks −6° HDTBR administration intravenous furosemide. Both led similar plasma volume. However, baseline decreased 20±4% 7±2% (interaction P<0.001). Moreover, was reduced more curve steeper orthostatic stress than hypovolemia. ...
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