Endothelium-dependent and independent dilation capability of peripheral arteries in patients with systemic lupus erythematosus and antiphospholipid syndrome.

摘要: OBJECTIVES The study evaluated the systemic inflammatory response and endothelium-dependent independent function of brachial artery (BA) in lupus erythematosus (SLE) patients with without antiphospholipid syndrome (APS). METHODS group consisted 42 women SLE (21 APS; mean age 36.1 ± 9.1, 21 43.9 13.1) 22 healthy controls (mean 43.5 10.3). Endothelium-dependent functional was evacuate using flow-mediated vasodilatation (FMD) endothelium-independent by application glyceryl trinitrate (GTN). Using biochemical methods, circulating markers were determined. RESULTS In comparison to controls, both groups dilation BA significantly reduced, there no differences FMD between or APS: - 7.7% (11.9-12.1), SLE+APS 7.8% (2.4-12.8), 14.6% (11.2-21.1), p<0.001. However, lower SLE-APS than also group: 24.3% (15.0-28.6), SLE+APS-17.4% (13.1-22.6), 23.0% (17.8-30.1), p=0.015 vs. p=0.027. Patients had higher values VCAM-1, hs-CRP, fibrinogen controls. SLE+APS, an additional significant increase registered. CONCLUSIONS results our indicate that have deteriorated those APS vascular which could be, together increased response, involved complications these patients. presence aggravates response.