Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.

摘要: Interleukin-6 (IL-6) is a multifunctional cytokine that proving to be major contributor the acute phase inflammatory response. IL-6 expression normally low and serum levels are usually nondetectable in absence of inflammation. With advancing age, however, become detectable it proposed this reflects an age-associated loss normal regulation gene for molecule. There also speculation may contribute pathogenesis several diseases common late-life including lymphoma, osteoporosis, Alzheimer's disease. In report we demonstrate plasma rise with age well-selected healthy elderly people comparably old rhesus monkeys. That change primary aging process suggested by our findings C57BL/6 mice which increase vitro synthesis largely prevented life span-extending dietary restriction.