Computational Biology of Olfactory Receptors.

摘要: Olfactory receptors, in addition to being involved first step of the physiological processes that leads olfaction, occupy an important place mammalian genomes. ORs constitute super families these Elucidating ol-factory receptor function at a molecular level can be aided by computationally derived structure and understanding its interactions with odor molecules. Experimental functional analyses olfactory receptors conjunction computational studies serve validate findings generate hypotheses. We present here review research efforts in: creating models identifying binding strategies for odorant molecules, performing medium long range simulation ligands region, amino acid positions within are responsible ligand-binding activation. Written as primer teaching tool, this will help researchers extend methodologies described herein other GPCRs.