Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC.
作者： Liang Kong , Shi-meng Zhang , Jia-hao Chu , Xin-ze Liu , Lu Zhang
DOI: 10.2147/IJN.S258906
关键词: MMP2 、 In vivo 、 Tumor microenvironment 、 Chemistry 、 Angiogenesis 、 Cancer research 、 Vinorelbine 、 A549 cell 、 Vasculogenic mimicry 、 Liposome
摘要: Background Non-small cell lung cancer (NSCLC) is one of the most lethal types with highly infiltrating. Chemotherapy far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration relapse. Purpose The objective this study was to construct a novel CPP (mmp) modified vinorelbine dioscin liposomes by two new functional materials, DSPE-PEG2000-MAL CPP-PVGLIG-PEG5000, destroy VM channels, angiogenesis, EMT inhibit invasion migration. Methods targeting could be enriched tumor sites through passive targeting, positively charged exposed enhanced active via electrostatic adsorption after being hydrolyzed MMP2 enzymes overexpressed microenvironment. We found that ideal physicochemical properties exhibited cellular uptake. In vitro vivo showed A549 cells, channels formation block process. Pharmacodynamic studies had obvious accumulations magnificent antitumor efficiency. Conclusion plus provide strategy for NSCLC.
sci-hub.st 参考文章(51)
Rilei Jiang, Cheng Hu, Qian Li, Ziyu Cheng, Ling Gu, Hongxiao Li, Yuanyuan Guo, Qirui Li, Yueyang Lu, Ke Li, Meijuan Chen, Xu Zhang, Sodium new houttuyfonate suppresses metastasis in NSCLC cells through the Linc00668/miR-147a/slug axis Journal of Experimental & Clinical Cancer Research. ,vol. 38, pp. 155- ,(2019) , 10.1186/S13046-019-1152-9
Jingjing Zhang, Zhiming Xu, Hongying Dai, Jing Zhao, Tingting Liu, Guiping Zhang, Silencing of Forkhead Box M1 Reverses Transforming Growth Factor-β1-Induced Invasion and Epithelial-Mesenchymal Transition of Endometriotic Epithelial Cells. Gynecologic and Obstetric Investigation. ,vol. 84, pp. 485- 494 ,(2019) , 10.1159/000499625
Yuanyuan Wang, Min Fu, Jingjing Liu, Yining Yang, Yibin Yu, Jinyu Li, Weisan Pan, Lei Fan, Guiru Li, Xuetao Li, Xiaobo Wang, Inhibition of tumor metastasis by targeted daunorubicin and dioscin codelivery liposomes modified with PFV for the treatment of non-small-cell lung cancer. International Journal of Nanomedicine. ,vol. 14, pp. 4071- 4090 ,(2019) , 10.2147/IJN.S194304
Danilo Rocco, Luigi Della Gravara, Ciro Battiloro, Cesare Gridelli, The role of combination chemo-immunotherapy in advanced non-small cell lung cancer. Expert Review of Anticancer Therapy. ,vol. 19, pp. 561- 568 ,(2019) , 10.1080/14737140.2019.1631800
Tangwei Wu, Hui Hu, Tianzhu Zhang, Liyuan Jiang, Xiaoyi Li, Shuiyi Liu, Chao Zheng, Ge Yan, Weiqun Chen, Yong Ning, Yong Li, Zhongxin Lu, miR-25 Promotes Cell Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Targeting the LATS2/YAP Signaling Pathway Oxidative Medicine and Cellular Longevity. ,vol. 2019, pp. 9719723- ,(2019) , 10.1155/2019/9719723
Qi Zhou, Liang Sun, Hongna Mu, Hongxia Li, Siming Wang, Xianghui Li, Wenxiang Chen, Jun Dong, Ruiyue Yang, Helu Xiu, Application of Urinary Polyphenol Biomarkers Measured by Liquid Chromatography Tandem Mass Spectrometry to Assess Polyphenol Intake and Their Association with Overweight and Obesity in Free-Living Healthy Subjects Oxidative Medicine and Cellular Longevity. ,vol. 2019, pp. 1- 11 ,(2019) , 10.1155/2019/4809836
Fang Li, Yu Wang, Wei-liang Chen, Dan-dan Wang, Ye-juan Zhou, Ben-gang You, Yang Liu, Chen-xi Qu, Shu-di Yang, Meng-tian Chen, Xue-nong Zhang, Co-delivery of VEGF siRNA and Etoposide for Enhanced Anti-angiogenesis and Anti-proliferation Effect via Multi-functional Nanoparticles for Orthotopic Non-Small Cell Lung Cancer Treatment. Theranostics. ,vol. 9, pp. 5886- 5898 ,(2019) , 10.7150/THNO.32416
Thiruganesh Ramasamy, Hima Bindu Ruttala, Kaliappan Kaliraj, Kishwor Poudel, Sung Giu Jin, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim, Polypeptide Derivative of Metformin with the Combined Advantage of a Gene Carrier and Anticancer Activity. ACS Biomaterials Science & Engineering. ,vol. 5, pp. 5159- 5168 ,(2019) , 10.1021/ACSBIOMATERIALS.9B00982
Liang Kong, Fu‐yi Cai, Xue‐min Yao, Ming Jing, Min Fu, Jing‐jing Liu, Si‐yu He, Lu Zhang, Xin‐ze Liu, Rui‐jun Ju, Xue‐tao Li, RPV-modified epirubicin and dioscin co-delivery liposomes suppress non-small cell lung cancer growth by limiting nutrition supply. Cancer Science. ,vol. 111, pp. 621- 636 ,(2020) , 10.1111/CAS.14256
Jinwei Pang, Jianhua Peng, Fang Cao, Zongduo Guo, Li Jiang, Zhipeng Teng, Zhijian Huang, Chongjie Cheng, Yong Jiang, Xiaochuan Sun, Yue Wu, Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice Oxidative Medicine and Cellular Longevity. ,vol. 2019, pp. 3832648- ,(2019) , 10.1155/2019/3832648