pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy
作者： Thiruganesh Ramasamy , Jeong Hwan Kim , Ju Yeon Choi , Tuan Hiep Tran , Han-Gon Choi
DOI: 10.1039/C4TB00867G
关键词: Polyelectrolyte 、 Mitoxantrone 、 Drug 、 Potency 、 Doxorubicin 、 Therapeutic effect 、 Micelle 、 Chemistry 、 Pharmacology 、 Combination chemotherapy 、 General Materials Science 、 General chemistry 、 Biomedical engineering 、 General Medicine
摘要: The co-encapsulation of two or more drugs in the same carrier affords synergistic therapeutic effects and enhanced potency. For this, polyethylene oxide-b-polyacrylic acid di-block polymer based-smart pH-sensitive polyelectrolyte complex (PEC) micelles were designed to encapsulate mitoxantrone (MTX) doxorubicin (DOX) with high payload capacity precise drug ratio. Three molar ratios (MTX/DOX: 2 : 1, 1 : 1, 1 : 2) drug-loaded PECs prepared evaluated for various physicochemical characteristics. dual combination exhibited a cytotoxic activity against both sensitive (MCF-7 A-549) resistant cancer cell lines (MDA-MB-231), unlike individual drugs. Dual nanosystems (MTX/DOX-M) prolonged blood circulation drugs, synergic ratio was maintained throughout study period. MTX/DOX-M superior efficacy xenograft models; by contrast, free cocktail caused significant loss body weight mice. Taken together, our results suggest that PEC have great potential as nano-scaled delivery systems chemotherapy.
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