Clinicopathological hallmarks and biomarkers of colorectal neuroendocrine neoplasms

摘要: Chromogranin A (CgA) is a well-established marker for diagnosis and follow up of patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). Recently, it has been shown that plasma levels CgA correlate tumor load predict survival NEN the small bowel. It assumed this as well valid colon rectum, however, not supported by data. To evaluate assumption, we analyzed 62 rectum listed in Marburg GEP-NEN registry clinicopathological characteristics, expression CgA. The present study demonstrates immunohistochemical synaptophysin are good markers histological rectum. However, poor to follow-up these because only minority exhibited increased which did increase significantly during progression. In contrast bowel, there no correlation burden or survival. Patients displayed relatively prognosis resulting median 8.5 years. subset affected G3 neoplasms, poorer 2.5 Taken together, valuable diagnosis, but concentration suitable mirror