Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases.
作者： Lincheng Zhang , Yutong Dong , Yiran Wang , Wenhui Hu , Shiwu Dong
DOI: 10.1111/JCMM.15155
关键词: Bone metastasis 、 Osteolysis 、 Bone resorption 、 Cell migration 、 Cancer research 、 Medicine 、 Bone regeneration 、 Immune system 、 Sphingosine-1-phosphate 、 Receptor
摘要: Sphingosine-1-phosphate (S1P) is a natural bioactive lipid molecule and common first or second messenger in the cardiovascular immune systems. By binding with its receptors, S1P can serve as mediator of signalling during cell migration, differentiation, proliferation apoptosis. Although predominant role bone regeneration has been noted many studies, this not well-known roles In review, we summarize previous research on receptors (S1PRs) osteoblasts osteoclasts. addition, regarded bridge between resorption formation, which brings hope to patients bone-related diseases. Finally, discuss therapeutic targets for treating osteoporosis, inflammatory osteolysis metastasis based biological effects osteoclastic/osteoblastic cells, cells tumour cells.
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