Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications.
作者： Jingjing Zhang , Wenqiang Tan , Lijie Wei , Yuan Chen , Yingqi Mi
DOI: 10.1016/J.CARBPOL.2019.03.067
关键词: Botrytis cinerea 、 Condensation reaction 、 Chitosan 、 Fusarium oxysporum 、 Asparagus 、 Nuclear chemistry 、 Antioxidant 、 Urea 、 Cytotoxicity 、 Chemistry
摘要: In the current study, five novel urea-functionalized chitosan derivatives were synthesized via condensation reactions of chloroacetyl (CTCS) with urea groups bearing nitrogen-containing heterocycles. order to identify structure characteristics derivatives, FT-IR, 1H NMR spectroscopy, and elemental analysis carried out. The antifungal activity against four species phytopathogen (Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, Fusarium cucumebrium Owen, Botrytis cinerea) was evaluated. Furthermore, antioxidant tested by hydroxyl-radical scavenging superoxide-radical assays. results indicated that displayed superior bioactivity compared chitosan. Besides, L929 cells adopted for cytotoxicity test samples CCK-8 assay all showed decreased cytotoxicity. These suggested could be an ideal biomaterial applications.
sci-hub.se 参考文章(40)
ER El-Sawy, MS Ebaid, HM Abo-Salem, AG Al-Sehemi, AH Mandour, None, Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of some new 4,6-dimethoxy-5-(heterocycles)benzofuran starting from naturally occurring visnagin Arabian Journal of Chemistry. ,vol. 7, pp. 914- 923 ,(2014) , 10.1016/J.ARABJC.2012.12.041
Warayuth Sajomsang, Pattarapond Gonil, Somsak Saesoo, Chitchamai Ovatlarnporn, Antifungal property of quaternized chitosan and its derivatives. International Journal of Biological Macromolecules. ,vol. 50, pp. 263- 269 ,(2012) , 10.1016/J.IJBIOMAC.2011.11.004
Rajesh H. Tale, Atish H. Rodge, Girish D. Hatnapure, Ashish P. Keche, The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: Synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation Bioorganic & Medicinal Chemistry Letters. ,vol. 21, pp. 4648- 4651 ,(2011) , 10.1016/J.BMCL.2011.03.062
Mohammad Azab, Mohamed Youssef, Eman El-Bordany, Synthesis and antibacterial evaluation of novel heterocyclic compounds containing a sulfonamido moiety. Molecules. ,vol. 18, pp. 832- 844 ,(2013) , 10.3390/MOLECULES18010832
Mohamed E.I. Badawy, Entsar I. Rabea, Nehad E.M. Taktak, Antimicrobial and inhibitory enzyme activity of N-(benzyl) and quaternary N-(benzyl) chitosan derivatives on plant pathogens Carbohydrate Polymers. ,vol. 111, pp. 670- 682 ,(2014) , 10.1016/J.CARBPOL.2014.04.098
P. Zoumpoulakis, Ch. Camoutsis, G. Pairas, M. Soković, J. Glamočlija, C. Potamitis, A. Pitsas, Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies Bioorganic & Medicinal Chemistry. ,vol. 20, pp. 1569- 1583 ,(2012) , 10.1016/J.BMC.2011.12.031
Ruilin Tang, Ying Zhang, Yang Zhang, Zhiming Yu, Synthesis and characterization of chitosan based dye containing quaternary ammonium group. Carbohydrate Polymers. ,vol. 139, pp. 191- 196 ,(2016) , 10.1016/J.CARBPOL.2015.12.047
Chunhua Wu, Jinhu Tian, Shan Li, Tiantian Wu, Yaqin Hu, Shiguo Chen, Tatsuya Sugawara, Xingqian Ye, Structural properties of films and rheology of film-forming solutions of chitosan gallate for food packaging. Carbohydrate Polymers. ,vol. 146, pp. 10- 19 ,(2016) , 10.1016/J.CARBPOL.2016.03.027
Jiangjiang Duan, Xichao Liang, Yan Cao, Sen Wang, Lina Zhang, High Strength Chitosan Hydrogels with Biocompatibility via New Avenue Based on Constructing Nanofibrous Architecture Macromolecules. ,vol. 48, pp. 2706- 2714 ,(2015) , 10.1021/ACS.MACROMOL.5B00117
Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Tongkai Cai, Wenjing Chu, Wenhao Hu, Yushe Yang, Design, Synthesis, and Structure–Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility Journal of Medicinal Chemistry. ,vol. 57, pp. 3687- 3706 ,(2014) , 10.1021/JM4016284