Sequential antigen panning for selection of broadly cross-reactive HIV-1-neutralizing human monoclonal antibodies.
作者： Mei-Yun Zhang , Dimiter S. Dimitrov
DOI: 10.1007/978-1-60327-302-2_11
关键词: Peptide library 、 Antigen 、 Antibody 、 Panning (camera) 、 Immunology 、 Biology 、 Monoclonal antibody 、 Primary and secondary antibodies 、 Epitope 、 Cancer cell 、 Virology
摘要: Many phage display techniques drive selection toward the isolation of highly specific antibodies. However, identification monoclonal antibodies that are cross-reactive has implications for development diagnostics, therapeutics, and vaccines against pathogens or cancer cells able to rapidly generate variants escape mutants. To identify human with high activity HIV broad-spectrum activity, we developed a technique termed sequential antigen panning. This methodology could be used isolated recombinant any shares epitopes other antigens.
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