Depression and Medication Adherence in Outpatients With Coronary Heart Disease: Findings From the Heart and Soul Study
作者： Anil Gehi , Donald Haas , Sharon Pipkin , Mary A. Whooley
DOI: 10.1001/ARCHINTE.165.21.2508
关键词: Cross-sectional study 、 Depression (differential diagnoses) 、 Ambulatory 、 Odds ratio 、 Psychiatry 、 Medicine 、 Confounding 、 Confidence interval 、 Prospective cohort study 、 Internal medicine 、 Social support
摘要: Background Depression leads to adverse outcomes in patients with coronary heart disease (CHD). Medication nonadherence is a potential mechanism for the increased risk of CHD events associated depression, but it not known whether depression medication outpatients stable CHD. Methods We examined association between current major (assessed using Diagnostic Interview Schedule) and self-reported adherence cross-sectional study 940 Results A total 204 participants (22%) had depression. Twenty-eight (14%) depressed reported taking their medications as prescribed compared 40 (5%) 736 nondepressed (odds ratio [OR], 2.8; 95% confidence interval [CI], 1.7-4.7; P = .01). The relationship persisted after adjustment confounding variables, including age, ethnicity, education, social support, measures cardiac severity (OR, 2.2; CI, 1.2-3.9; = .009 prescribed). Conclusions may contribute cardiovascular patients.
sci-hub.se 参考文章(57)
Rampmaier J, Kruse W, Weber E, Ullrich G, Patterns of drug compliance with medications to be taken once and twice daily assessed by continuous electronic monitoring in primary care. International Journal of Clinical Pharmacology and Therapeutics. ,vol. 32, pp. 452- 457 ,(1994)
Robert M Carney, Kenneth E Freedland, Gregory E Miller, Allan S Jaffe, Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. Journal of Psychosomatic Research. ,vol. 53, pp. 897- 902 ,(2002) , 10.1016/S0022-3999(02)00311-2
D. Levitan Robert, G. Blouin Arthur, R. Navarro Joaquin, James Hill, Validity of the computerized DIS for diagnosing psychiatric inpatients. The Canadian Journal of Psychiatry. ,vol. 36, pp. 728- 731 ,(1991) , 10.1177/070674379103601006
Effects of an angiotensin-converting -enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients The New England Journal of Medicine. ,vol. 342, pp. 145- 153 ,(2000) , 10.1056/NEJM200001203420301
Jane Irvine, Brian Baker, Janice Smith, Stacey Jandciu, Miney Paquette, John Cairns, Stuart Connolly, Robin Roberts, Michael Gent, Paul Dorian, Poor Adherence to Placebo or Amiodarone Therapy Predicts Mortality: Results From the CAMIAT Study Psychosomatic Medicine. ,vol. 61, pp. 566- 575 ,(1999) , 10.1097/00006842-199907000-00023
Gary R. Cutter, Gregory L. Burke, Alan R. Dyer, Gary D. Friedman, Joan E. Hilner, Glenn H. Hughes, Stephen B. Hulley, David R. Jacobs, Kiang Liu, Teri A. Manolio, Albert Oberman, Laura L. Perkins, Peter J. Savage, Joyce R. Serwitz, Stephen Sidney, Lynne E. Wagenknecht, Cardiovascular risk factors in young adults: The CARDIA baseline monograph Controlled Clinical Trials. ,vol. 12, pp. 1- 77 ,(1991) , 10.1016/0197-2456(91)90002-4
Robert L. Spitzer, The Structured Clinical Interview for DSM-III-R (SCID) Archives of General Psychiatry. ,vol. 49, pp. 624- 629 ,(1992) , 10.1001/ARCHPSYC.1992.01820080032005
Robert Horne, John Weinman, Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness Journal of Psychosomatic Research. ,vol. 47, pp. 555- 567 ,(1999) , 10.1016/S0022-3999(99)00057-4
Dominique L Musselman, Ephi Betan, Hannah Larsen, Lawrence S Phillips, Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment Biological Psychiatry. ,vol. 54, pp. 317- 329 ,(2003) , 10.1016/S0006-3223(03)00569-9
Christian Otte, Charles R. Marmar, Sharon S. Pipkin, Rudolf Moos, Warren S. Browner, Mary A. Whooley, Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study Biological Psychiatry. ,vol. 56, pp. 241- 247 ,(2004) , 10.1016/J.BIOPSYCH.2004.06.003