Necrosulfonamide – Unexpected effect in the course of a sulfur mustard intoxication
作者： Georg Menacher , Frank Balszuweit , Simon Lang , Horst Thiermann , Kai Kehe
DOI: 10.1016/J.CBI.2018.10.030
关键词: HaCaT 、 Interleukin 、 Sulfur mustard 、 Apoptosis 、 Inflammation 、 Programmed cell death 、 Necrosis 、 Pharmacology 、 Medicine 、 Necroptosis 、 Toxicology 、 General Medicine
摘要: Abstract Although its first military use in Ypres was 100 years ago, no causal therapy for sulfur mustard (SM) intoxications exists so far. To improve the therapeutic options treatment of SM intoxications, we developed a co-culture keratinocytes (HaCaT cells) and immunocompetent cells (THP-1 cells) to identify potential substances further research. Here, report on influence necrosulfonamide (NSA) course intoxication vitro. The were challenged with 100, 200 300 μM after 1 h treated NSA (1, 5, 10 μM). chosen known ability inhibit necroptosis, specialized pathway programmed necrosis. However, our settings showed only mild effects necrotic cell death intoxication, whereas it had an immense prevent apoptosis. Furthermore, able reduce production interleukin-6 interleukin-8 at certain concentrations. Our data highlight as candidate compound address inflammation exposure.
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