Vestibular inputs elicit patterned changes in limb blood flow in conscious cats

摘要: Previous experiments have demonstrated that the vestibular system contributes to regulating sympathetic nervous activity, particularly discharges of vasoconstrictor fibres. In present study, we examined physiological significance vestibulosympathetic responses by comparing blood flow and vascular resistance in forelimb hindlimb during head-up tilt from prone position before after removal inputs through a bilateral neurectomy. Experiments were performed on conscious cats trained remain sedentary table rotations up 60 deg amplitude. Blood femoral brachial arteries was recorded whole-body using perivascular probes; pressure telemetry calculated measurements. vestibular-intact animals, produced ∼20% decrease ∼37% increase relative baseline levels tilt; similar effects also observed for artery (∼25% ∼38% resistance). Following inputs, almost unchanged. contrast, increased only ∼6% rotation delivered first week elimination signals ∼16% subsequent 3-week period (as opposed occurred lesion). These data demonstrate associated with postural alterations elicit regionally specific increases direct away region body where pooling may occur. Thus, support hypothesis influences cardiovascular serve protect against occurrence orthostatic hypotension.