Imaging and quantification of iron-oxide nanoparticles (IONP) using MP-RAGE and UTE based sequences.
作者： Wen Hong , Qun He , Shujuan Fan , Michael Carl , Hongda Shao
DOI: 10.1002/MRM.26371
关键词: Linear relationship 、 Quantitative assessment 、 Nuclear magnetic resonance 、 Ultrashort echo time 、 Imaging phantom 、 Iron oxide nanoparticles 、 Materials science
摘要: Author(s): Hong, Wen; He, Qun; Fan, Shujuan; Carl, Michael; Shao, Hongda; Chen, Jun; Chang, Eric Y; Du, Jiang | Abstract: PurposeTo investigate two-dimensional (2D) and three-dimensional (3D) ultrashort echo time (UTE) 3D magnetization-prepared rapid gradient-echo (MP-RAGE) sequences for the imaging of iron-oxide nanoparticles (IONP).MethodsThe phantoms were composed tubes filled with different IONP concentrations ranging from 2 to 45 mM. The fixed in an agarose gel phantom (0.9% by weight). Morphological was performed MP-RAGE, 2D UTE, adiabatic inversion recovery-prepared UTE (2D IR-UTE), Cones trajectory (3D Cones), IR-Cones sequences. Quantitative assessment concentration using R2*(1/T2*) R1 (1/T1 ) measurements a 3 Tesla (T) scanner.ResultsThe MP-RAGE sequence provides high-contrast images up 7.5 Higher 37.5 mM can be detected sequences, highest contrast provided sequence. A linear relationship observed between R2* ∼45 mM, ∼30 mM.ConclusionThe clinical used assess lower higher Magn Reson Med 78:226-232, 2017. © 2016 International Society Magnetic Resonance Medicine.
sci-hub.se 参考文章(39)
Jiang Du, Graeme M. Bydder, Qualitative and quantitative ultrashort-TE MRI of cortical bone. NMR in Biomedicine. ,vol. 26, pp. 489- 506 ,(2013) , 10.1002/NBM.2906
Jinjin Zhang, Ryan Chamberlain, Michael Etheridge, Djaudat Idiyatullin, Curtis Corum, John Bischof, Michael Garwood, Quantifying iron‐oxide nanoparticles at high concentration based on longitudinal relaxation using a three‐dimensional SWIFT look‐locker sequence Magnetic Resonance in Medicine. ,vol. 71, pp. 1982- 1988 ,(2014) , 10.1002/MRM.25181
Luning Wang, Curtis A. Corum, Djaudat Idiyatullin, Michael Garwood, Qun Zhao, T1 estimation for aqueous iron oxide nanoparticle suspensions using a variable flip angle SWIFT sequence Magnetic Resonance in Medicine. ,vol. 70, pp. 341- 347 ,(2013) , 10.1002/MRM.24831
Michael Carl, Graeme M. Bydder, Jiang Du, UTE imaging with simultaneous water and fat signal suppression using a time-efficient multispoke inversion recovery pulse sequence. Magnetic Resonance in Medicine. ,vol. 76, pp. 577- 582 ,(2016) , 10.1002/MRM.25823
Jiang Du, Juan C. Hermida, Eric Diaz, Jacqueline Corbeil, Richard Znamirowski, Darryl D. D'Lima, Graeme M. Bydder, Assessment of cortical bone with clinical and ultrashort echo time sequences Magnetic Resonance in Medicine. ,vol. 70, pp. 697- 704 ,(2013) , 10.1002/MRM.24497
Matthew D. Robson, Peter D. Gatehouse, Mark Bydder, Graeme M. Bydder, Magnetic resonance: an introduction to ultrashort TE (UTE) imaging. Journal of Computer Assisted Tomography. ,vol. 27, pp. 825- 846 ,(2003) , 10.1097/00004728-200311000-00001
Kenneth P Batts, Iron overload syndromes and the liver. Modern Pathology. ,vol. 20, ,(2007) , 10.1038/MODPATHOL.3800715
Bozho Todorich, Juana M. Pasquini, Corina I. Garcia, Pablo M. Paez, James R. Connor, Oligodendrocytes and myelination: the role of iron. Glia. ,vol. 57, pp. 467- 478 ,(2009) , 10.1002/GLIA.20784
Claude B. Sirlin, Scott B. Reeder, Magnetic Resonance Imaging Quantification of Liver Iron Magnetic Resonance Imaging Clinics of North America. ,vol. 18, pp. 359- 381 ,(2010) , 10.1016/J.MRIC.2010.08.014
Nilesh R. Ghugre, Cathleen M. Enriquez, Ignacio Gonzalez, Marvin D. Nelson, Thomas D. Coates, John C. Wood, MRI Detects Myocardial Iron in the Human Heart Magnetic Resonance in Medicine. ,vol. 56, pp. 681- 686 ,(2006) , 10.1002/MRM.20981