Carbapenem-Resistant Pseudomonas aeruginosa Bacteremia: Risk Factors for Mortality and Microbiologic Treatment Failure.
作者： Deanna J. Buehrle , Ryan K. Shields , Lloyd G. Clarke , Brian A. Potoski , Cornelius J. Clancy
DOI: 10.1128/AAC.01243-16
关键词: Carbapenem resistant Pseudomonas aeruginosa 、 Treatment failure 、 Antimicrobial 、 Internal medicine 、 Bacteremia 、 Medicine 、 Retrospective cohort study 、 Young adult 、 Antibiotics 、 Pseudomonas aeruginosa
摘要: We reviewed 37 patients treated for bacteremia due to carbapenem-resistant (CR) Pseudomonas aeruginosa Although 65% of isolates were multiple-drug resistant, therapeutic options available, as all susceptible ≥1 antibiotic. A total 92% received active antimicrobial therapy, but only 57% early therapy (within 48 h). Fourteen-day mortality was 19%. Microbiologic failure occurred in 29%. The Pitt score (P = 0.046) and delayed 0.027) predictive death microbiologic failure, respectively.
sci-hub.se 参考文章(35)
Chia-Hsin Lee, Ting-Yi Su, Jung-Jr Ye, Po-Chang Hsu, An-Jing Kuo, Ju-Hsin Chia, Ming-Hsun Lee, Risk factors and clinical significance of bacteremia caused by Pseudomonas aeruginosa resistant only to carbapenems. Journal of Microbiology Immunology and Infection. ,vol. 50, pp. 677- 683 ,(2017) , 10.1016/J.JMII.2015.06.003
C. J. Clancy, L. Chen, R. K. Shields, Y. Zhao, S. Cheng, K. D. Chavda, B. Hao, J. H. Hong, Y. Doi, E. J. Kwak, F. P. Silveira, R. Abdel-Massih, T. Bogdanovich, A. Humar, D. S. Perlin, B. N. Kreiswirth, M. Hong Nguyen, Epidemiology and Molecular Characterization of Bacteremia Due to Carbapenem-Resistant Klebsiella pneumoniae in Transplant Recipients American Journal of Transplantation. ,vol. 13, pp. 2619- 2633 ,(2013) , 10.1111/AJT.12424
Helio S. Sader, Mariana Castanheira, Robert K. Flamm, Rodrigo E. Mendes, David J. Farrell, Ronald N. Jones, Tigecycline activity tested against carbapenem-resistant Enterobacteriaceae from 18 European nations: results from the SENTRY surveillance program (2010–2013) Diagnostic Microbiology and Infectious Disease. ,vol. 83, pp. 183- 186 ,(2015) , 10.1016/J.DIAGMICROBIO.2015.06.011
Ryan K. Shields, Eun J. Kwak, Brian A. Potoski, Yohei Doi, Jennifer M. Adams-Haduch, Fernanda P. Silviera, Yoshiya Toyoda, Joseph M. Pilewski, Maria Crespo, A. William Pasculle, Cornelius J. Clancy, M. Hong Nguyen, High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. Diagnostic Microbiology and Infectious Disease. ,vol. 70, pp. 246- 252 ,(2011) , 10.1016/J.DIAGMICROBIO.2010.12.023
Te-Din Huang, Catherine Berhin, Pierre Bogaerts, Youri Glupczynski, a multicentre study group, J Caddrobi, I Leroux, G Claeys, E Oris, G Coppens, A Dediste, O Vandenberg, Y Degheldre, C Nonhoff, O Denis, A Smismans, J Frans, M-G Garrino, J-S Goffinet, T-D Huang, Y Glupczynski, M Ieven, B Lissoir, K Magerman, M Dodemont, P Melin, Y Miendje, E Nulens, A Schallier, D Pierard, A Pernet, C Potvliege, H Rodriguez-Villalobos, A Simon, M Carpentier, J-M Senterre, K Van Vaerenbergh, A Boel, A-M Vandenabeele, V Verbelen, V Saegeman, Jan Verhaegen, None, Prevalence and mechanisms of resistance to carbapenems in Enterobacteriaceae isolates from 24 hospitals in Belgium Journal of Antimicrobial Chemotherapy. ,vol. 68, pp. 1832- 1837 ,(2013) , 10.1093/JAC/DKT096
Zakuan Zainy Deris, Hans Van Rostenberghe, Hassan Habsah, Ramli Noraida, Gin Ceong Tan, Yean Yean Chan, Abdul Rahman Rosliza, Manicham Ravichandran, None, First isolation of Burkholderia tropica from a neonatal patient successfully treated with imipenem International Journal of Infectious Diseases. ,vol. 14, ,(2010) , 10.1016/J.IJID.2009.03.005
Eun-Jeong Joo, Cheol-In Kang, Young Eun Ha, Seung-Ji Kang, So Yeon Park, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song, Risk factors for mortality in patients with Pseudomonas aeruginosa bacteremia: clinical impact of antimicrobial resistance on outcome. Microbial Drug Resistance. ,vol. 17, pp. 305- 312 ,(2011) , 10.1089/MDR.2010.0170
Cheol‐In Kang, Sung‐Han Kim, Hong‐Bin Kim, Sang‐Won Park, Young‐Ju Choe, Myoung‐don Oh, Eui‐Chong Kim, Kang‐Won Choe, Pseudomonas aeruginosa Bacteremia: Risk Factors for Mortality and Influence of Delayed Receipt of Effective Antimicrobial Therapy on Clinical Outcome Clinical Infectious Diseases. ,vol. 37, pp. 745- 751 ,(2003) , 10.1086/377200
Lawrence F Muscarella, Risk of transmission of carbapenem-resistantEnterobacteriaceaeand related “superbugs” during gastrointestinal endoscopy World Journal of Gastrointestinal Endoscopy. ,vol. 6, pp. 457- 474 ,(2014) , 10.4253/WJGE.V6.I10.457
Ming-Han Tsai, Tsu-Lan Wu, Lin-Hui Su, Wei-Lin Lo, Chyi-Liang Chen, Yi-Hua Liang, Cheng-Hsun Chiu, Carbapenem-resistant-only Pseudomonas aeruginosa infection in patients formerly infected by carbapenem-susceptible strains. International Journal of Antimicrobial Agents. ,vol. 44, pp. 541- 545 ,(2014) , 10.1016/J.IJANTIMICAG.2014.07.022