Involvement of chloride channel coupled GABAC receptors in the peripheral antinociceptive effect induced by GABAC receptor agonist cis-4-aminocrotonic acid
作者： Gláucia Maria Lopes Reis , Igor Dimitri Gama Duarte
DOI: 10.1016/J.LFS.2006.12.015
关键词: Potassium channel blocker 、 Pharmacology 、 GABA receptor antagonist 、 Potassium channel 、 Chloride channel 、 Endocrinology 、 Randall–Selitto test 、 Internal medicine 、 Chemistry 、 Receptor antagonist 、 Picrotoxin 、 Agonist 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: We investigated the effect of chloride and potassium channel blockers on antinociception induced by GABA(C) receptor agonist CACA (cis-4-aminocrotonic acid) using paw pressure test, in which pain sensitivity was increased an intraplantar injection (2 microg) prostaglandin E(2) (PGE(2)). administered locally into right hindpaw (25, 50 100 microg/paw) elicited a dose-dependent antinociceptive demonstrated to be local, since only higher doses produced when injected contralateral paw. The antagonist (1,2,5,6 tetrahydropyridin-4-yl) methylphosphinic acid (TPMPA; 5, 10 20 antagonized, manner, peripheral (100 microg), suggesting specific effect. This reversed coupled blocker picrotoxin (0.8 microg/paw). Glibenclamide (160 tolbutamide (320 ATP-sensitive channels, charybdotoxin large-conductance blocker, dequalinium (50 small-conductance cesium (500 non-specific did not modify CACA. study provides evidence that activation receptors periphery induces antinociception, this results from channels appear involved.
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