Terpenoids—LV : Cyclocostunolides
作者： G.H. Kulkarni , G.R. Kelkar , S.C. Bhattacharyya
DOI: 10.1016/S0040-4020(01)90842-7
关键词: Amide 、 Catalytic hydrogenation 、 Ammonia 、 Alkali metal 、 Terpenoid 、 Methanol 、 Costunolide 、 Chemistry 、 Organic chemistry 、 Saponification
摘要: Abstract α-cyclocostunolide (IV), a product of transannular crystaliaton costunolide, gives, on treatment with methanol in presence alkali, (1) α-cyclo-12-methoxydihydrocostunoide (VII) and (2) the corresponding hydroxy acid (VIII). On ammonia, is converted to amide (IX), saponification which ields VIII. The (VIII) catalytic hydrogenation gives saturated (X) lactonizes santanolide ‘c’ acid.
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