The value of postmortem examination in cases of metastasis of unknown origin-20-year retrospective data from a tertiary care center.

摘要: Abstract Background Metastasis of unknown origin (MUO) is a diagnostic challenge in clinical practice even with the state current advanced technology. To evaluate value autopsy determining primary site MUO, this study reviewed Hamilton experience—over last 20 years—with patients autopsied diagnosis MUO. Methods All diagnoses from cases performed at Health Sciences Center and St Joseph's Healthcare 1980 to 2000 were reviewed. Fifty-three MUO identified (MUO was defined as patient pathological and/or radiological metastatic tumor for which malignancy unknown). The history gross microscopic these Results There 31 men (58.5%) 22 women (41.5%) study. Their mean age 66 years. Pathological adenocarcinoma (n = 37), small cell carcinoma 6), anaplastic 3), undifferentiated 3). Primary tumors 27 (51%), most commonly lung 8), large bowel pancreas 4). Histochemical immunohistochemical stains helpful reaching 4 cases. Conclusions following observed: (1) series, establishing 51% cases, reaffirming postmortem examination instances; (2) frequent presenting MUO; (3) sites tumors; (4) careful histological examinations remain important tools identifying site.