Method of binding using irradiation and product with albumin bound to biomaterials

作者: Kalpana R. Kamath , Kinam Park

DOI:

关键词: Double bondCoatingMoleculeRadicalIrradiationPolymer chemistryOrganic chemistryCovalent bondPenetration (firestop)Materials scienceEpoxy

摘要: A medical device has one or more polymeric substrates each treated with a chemically binding coating to make substrate compatible for contact blood. modified natural and substantially hydrophilic blood protein bonds permanently substrate. The is functionalized bonding sites so after application thereof if subject sufficient radiation, free radicals created on the bind. modifier added creates by functionalizing it before combination applied human animal albumin as bovine. are molecules having an epoxy function attachment albumin. An unsaturated double bond forms accepts at sites. glycidyl acrylate. single carbon atom of carbon-carbon which together form covalent bond. radiation gamma electron beam. in extracorporeal circuit permit penetration rays. method steps selecting protein; adding creating functionalize substrate; applying substrate, combination. includes irradiating sufficiently create coated binding.