Improving Vaccine Potency Through Intercellular Spreading and Enhanced MHC Class I Presentation of Antigen
作者： Chien-Fu Hung , Wen-Fang Cheng , Chee-Yin Chai , Keng-Fu Hsu , Liangmei He
DOI: 10.4049/JIMMUNOL.166.9.5733
关键词: Antigen presentation 、 Virology 、 Potency 、 Vaccine Potency 、 Antigen 、 Intercellular transport 、 CD8 、 DNA vaccination 、 MHC class I 、 Biology
摘要: The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, a HSV-1 protein, has demonstrated the remarkable property intercellular transport may thus provide unique approach for enhancing vaccine potency. Therefore, we created novel fusion VP22 with model Ag, human papillomavirus type 16 E7, that generated enhanced spreading MHC class I presentation AG: These properties led dramatic increase number E7-specific CD8(+) T cell precursors vaccinated mice (around 50-fold) converted less effective into one significant against E7-expressing tumors. In comparison, nonspreading VP22(1-267) mutants failed enhance Our data indicated be dramatically improved through Ag.
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