Experimental modeling of cornea wound healing in diabetes: clinical applications and beyond.

摘要: Diabetes mellitus is the most common cause of blindness in working age populations worldwide. While much focus for public health has been on secondary prevention sight-threatening diabetic retinopathy, cornea, including its epithelium and nerves, represents a major site damage by chronic hyperglycemia. On injury, cornea exhibits delayed wound-healing response, as well an altered ocular surface immune response. This suggests potential association between dysfunctional wound healing response inflammation surface. However, presence confounders makes this difficult to investigate human epidemiological studies. Thus, we turn animal models better understanding. In review, 20 original studies, published 2008 2018, describe vivo vitro disease. We compared different discussed relative strengths drawbacks each model. A number molecular cellular components involved corneal that are diabetes have identified reviewed Particularly, epithelial protein concentrations lumician occludin were detected eyes with controls. Additionally, importance IL-1β modulating inflammatory after injury patients controls was further elucidated. Meanwhile, abnormal P2×7 receptor localization decreased sub-basal nerve density shown contribute signaling thus affecting Finally, discovery therapeutic effects topically administered aloe vera, Serpine 1, Resolvin D1 (RvD1), pigment epithelium-derived factor (PEDF) Pro-His-Ser-Arg-Asn provide encouraging evidence future availability effective treatment keratopathy.