Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke
作者： Ming-Hsiu Wu , Chao-Ching Huang , Chung-Ching Chio , Kuen-Jer Tsai , Ching-Ping Chang
DOI: 10.1007/S12035-015-9418-5
关键词: Microglia 、 Stroke recovery 、 Microgliosis 、 Etanercept 、 Neuroinflammation 、 Pharmacology 、 Medicine 、 Immunology 、 Downregulation and upregulation 、 Tumor necrosis factor alpha 、 Cerebral blood flow
摘要: Ischemic stroke, caused by obstruction of blood flow to the brain, would initiate microglia activation which contributes neuronal damage. Therefore, inhibition microglia-mediated neuroinflammation could be a therapeutic strategy for ischemic stroke. This study was aimed elucidate anti-inflammatory effects alpha-lipoic acid and etanercept given either singly or in combination rats subjected middle cerebral artery occlusion. Both α-lipoic markedly reduced infarct, blood-brain barrier disruption, neurological motor deficits with former drug being more effective dosage used. Furthermore, when used combination, reduction substantial. Remarkably, greater diminution serum levels tumor necrosis factor-alpha as well brain microglial (e.g., microgliosis, amoeboid microglia, overexpression factor-α) observed combined treatment compared drugs separately. We conclude that peripheral downregulation protect rat against Moreover, both were stroke recovery promoted extensively.
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Horatiu Dinu, Mihai Berteanu, Bogdan Nicolae Manolescu, Delia Cinteza, Suzana Vladoiu, The Consumption of Alanerv® Nutritional Supplement and the Dynamic of Some Inflammatory Markers in Post-Acute Stroke Patients Undergoing Rehabilitation Mædica. ,vol. 8, pp. 137- 142 ,(2013)
Antonino Tuttolomondo, Rosaria Pecoraro, Alessandra Casuccio, Domenico Di Raimondo, Carmelo Buttà, Giuseppe Clemente, Vittoriano della Corte, Giuliana Guggino, Valentina Arnao, Carlo Maida, Irene Simonetta, Rosario Maugeri, Rosario Squatrito, Antonio Pinto, Peripheral frequency of CD4+ CD28- cells in acute ischemic stroke: relationship with stroke subtype and severity markers. Medicine. ,vol. 94, pp. 1- 8 ,(2015) , 10.1097/MD.0000000000000813
Alessio Albanese, Antonio Tuttolomondo, Carmelo Anile, Giovanni Sabatino, Angelo Pompucci, Antonio Pinto, Guiseppe Licata, Annunziato Mangiola, Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII : Report of three cases Journal of Neurosurgery. ,vol. 102, pp. 1130- 1132 ,(2005) , 10.3171/JNS.2005.102.6.1130
Chung-Ching Chio, Jia-Wei Lin, Ming-Wen Chang, Che-Chuan Wang, Jinn-Rung Kuo, Chung-Zhing Yang, Ching-Ping Chang, Therapeutic evaluation of etanercept in a model of traumatic brain injury. Journal of Neurochemistry. ,vol. 115, pp. 921- 929 ,(2010) , 10.1111/J.1471-4159.2010.06969.X
A. Tuttolomondo, D. Di Raimondo, R. Di Sciacca, A. Casuccio, G. Bivona, C. Bellia, L. Barreca, A. Serio, G. D’Aguanno, M. Ciaccio, G. Licata, A. Pinto, Fetuin-A and CD40 L plasma levels in acute ischemic stroke: Differences in relation to TOAST subtype and correlation with clinical and laboratory variables Atherosclerosis. ,vol. 208, pp. 290- 296 ,(2010) , 10.1016/J.ATHEROSCLEROSIS.2009.07.032
Giovanni Davì, Antonino Tuttolomondo, Francesca Santilli, Stefania Basili, Elisabetta Ferrante, Domenico Di Raimondo, Antonio Pinto, Giuseppe Licata, CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke. Journal of Atherosclerosis and Thrombosis. ,vol. 16, pp. 707- 713 ,(2010) , 10.5551/JAT.1537
Antonio Pinto, Domenico Di Raimondo, Antonino Tuttolomondo, Paola Fernandez, Valentina Arna, Giuseppe Licata, Twenty-four hour ambulatory blood pressure monitoring to evaluate effects on blood pressure of physical activity in hypertensive patients. Clinical Journal of Sport Medicine. ,vol. 16, pp. 238- 243 ,(2006) , 10.1097/00042752-200605000-00009
R. Brouns, P.P. De Deyn, The complexity of neurobiological processes in acute ischemic stroke Clinical Neurology and Neurosurgery. ,vol. 111, pp. 483- 495 ,(2009) , 10.1016/J.CLINEURO.2009.04.001
V. Bramanti, D. Tomassoni, D. Bronzi, S. Grasso, M. Currò, M. Avitabile, G. Li Volsi, M. Renis, R. Ientile, F. Amenta, R. Avola, Alpha-Lipoic Acid Modulates GFAP, Vimentin, Nestin, Cyclin D1 and MAP-Kinase Espression in Astroglial Cell Cultures Neurochemical Research. ,vol. 35, pp. 2070- 2077 ,(2010) , 10.1007/S11064-010-0256-6
P. Wolz, J. Krieglstein, Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia Neuropharmacology. ,vol. 35, pp. 369- 375 ,(1996) , 10.1016/0028-3908(95)00172-7