Obestatin and Its Fragments: A New Approach to the Regulation of Body Weight under Normal and Pathological Conditions

摘要: Gastrointestinal diseases and eating disorders are among the most common pathologies in world. One of widespread dangerous consequence many is an uncontrolled weight gain that often leads to obesity. This review focuses on 15-year-long studies obestatin, one potential regulators behavior. peptide contains 23 amino-acids appears due processing preproghrelin gene responsible for coding another orexigenic protein ghrelin. Obestatin ghrelin have multiple physiological functions, including appetite regulation. was originally obtained from gastric mucosa rats, but subsequent showed it could be expressed various tissues had different effects organs tissues. emphasizes possible anorexigenic this their mechanisms. Despite 15 years research its influence mechanism particular bring about a lot discussion. primarily ambiguity receptors’ determination also related degradation molecule into small fragments, which, turn, can own effects. The local obestatin derivatives peripheral effect at central level indicate these peptides further studies. For example, compounds considered as therapeutic disorders’ treatment. aim work describe relevance problem associated with obesity treatment summarize results numerous fragments regulation order explain