Light on the structural communication in Ras GTPases.

摘要: The graph theory was combined with fluctuation dynamics to investigate the structural communication in four small G proteins, Arf1, H-Ras, RhoA, and Sec4. topology of GTPases is such that it requires presence nucleotide acquire a persistent network. majority paths involves does not exist unbound forms. latter are almost devoid high-frequency paths. Thus, Ras ability transfer signals nucleotide, suggesting modifies intrinsic protein through establishment regions hyperlinked nodes high occurrence correlated motions. analysis inactive (SGDP) active (SGTP) states proteins strengthened separation Ras-like domain into two dynamically distinct lobes, i.e. lobes 1 2, representing, respectively, N-terminal C-terminal halves domain. In framework th...