Combined detection of urine specific gravity and BK viruria on prediction of BK polyomavirus nephropathy in kidney transplant recipients.

摘要: Background: BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) is an important cause of dysfunction and failure renal transplants. This study aimed to assess the diagnostic performance morning urine specific gravity (MUSG) in diagnosing BKPyVAN kidney transplant recipients. Methods: A total 87 patients, including 27 with BKPyVAN, 22 isolated BKPyV viruria, 18 T cell-mediated rejection(TCMR), 20 stable graft function, were enrolled First Affiliated Hospital Sun Yat-Sen University from March 2015 February 2017. MUSG at biopsy during a follow-up period 24 months after was collected analyzed. Receiver operating characteristic (ROC) curve analysis used determine ability discriminate BKPyVAN. Results: At biopsy, group (1.008 ± 0.003) significantly lower than that BK viruria group(1.013 0.004, P < 0.001), TCMR (1.011 0.003, = 0.027), control (1.014 0.006, 0.001). There no significant difference among group, (P 0.253). In timing trend elevate consistent decline viral load plasma, reaching statistical 3 treatment (1.012 0.001) compared values diagnosis. ROC indicated optimal cut-off value for diagnosis 1.009, area under (AUC) 0.803 (95% confidence interval [CI]: 0.721–0.937). For differentiating TCMR, 1.010, AUC 0.811 CI: 0.687–0.934). Conclusion: Combined detection valuable predicting distinguishing recipients. Key words: BK polyomavirus; Kidney transplantation; Nephropathy; Rejection; Urinalysis