Is Methioninase Useful for the Prevention of Hyperhomocysteinemia-Associated Cardiovascular Disease?

作者: Robert M. Hoffman

DOI: 10.1007/978-1-4615-5771-5_21

关键词: Vitamin b6HyperhomocysteinemiaMedicineArteriosclerosisVitamin B12Internal medicineFramingham Heart StudyCardiologyPlasma homocysteineDiseaseHomocysteine

摘要: In 1969, McCully concluded that homocysteine is a causative agent in arterioscleosis [1]. A recently study of 1,041 people from the Framingham Heart Study found elevated plasma leads to an increased risk arteriosclerosis [2]. Other studies [2] have linked even moderate hyperhomocysteinemia peripheral vascular, cerebrovascular, and coronary heart disease. Although vitamin B12, B6, folate therapy been suggested lower hyperhomocysteinemia, acute medical intervention may be indicated for large fraction individuals at this

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