Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus.
作者： Hong Sun , HaiQin Wu , Xin Yu , GuiLian Zhang , Ru Zhang
DOI: 10.1016/J.MCN.2015.02.014
关键词: Angiotensin II 、 Epilepsy 、 Status epilepticus 、 Angiotensin II receptor type 1 、 Neuroscience 、 Angiotensin receptor 、 Losartan 、 Neuroinflammation 、 Biology 、 Neuroprotection 、 Pharmacology
摘要: Neuroinflammation plays a role in the pathology of epilepsy and cognitive impairment. Angiotensin II (AII) angiotensin receptor type 1 (AT1) have been shown to regulate seizure susceptibility different models epilepsy. Inhibition AT1 attenuates neuroinflammatory responses neurological diseases. In present study, we showed that protein expression AII was increased activated microglia following lithium pilocarpine-induced status epilepticus (SE) rats. Furthermore, antagonist, losartan, significantly inhibited SE-induced impairment microglia-mediated inflammation. Losartan also prevented SE induced neuronal loss hippocampus exerted neuroprotection. These data suggest losartan improves by suppressing mediated inflammatory attenuating hippocampal loss. Overall, our findings provide possible therapeutic strategy for treatment
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