Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes

摘要: Microbial communities contain diverse bacteria that play important roles in every environment. Advances sequencing and computational methodologies over the past decades have illuminated phylogenetic functional diversity of microbial from habitats. Among activities encoded microbiomes are abilities to synthesize resist small molecules, yielding antimicrobial activity. These functions particular interest when viewed light public health emergency posed by increase clinical resistance dwindling discovery approval pipeline, given intimate ecological evolutionary relationship between biosynthesis resistance. Here, we review genomic methods been developed for accessing capacity highlight outstanding examples their applications.