Central nervous system-specific knockout of steroidogenic factor 1.
作者： Ki Woo Kim , Liping Zhao , Keith L. Parker
DOI: 10.1016/J.MCE.2008.09.026
关键词: Steroidogenic factor 1 、 Cell biology 、 Energy homeostasis 、 Phenotype 、 Adrenocortical Insufficiency 、 Knockout mouse 、 Nuclear receptor 、 Homeostasis 、 Central nervous system 、 Endocrinology 、 Internal medicine 、 Biology
摘要: Steroidogenic factor 1 (SF-1) is a nuclear receptor that plays important roles in the hypothalamus-pituitary-steroidogenic organ axis. Global knockout studies mice revealed essential vivo of SF-1 ventromedial hypothalamic (VMH) nucleus, adrenal glands, and gonads. One limitation global their early postnatal death from adrenocortical insufficiency. To overcome limitations to delineate brain, we used Cre/loxP recombination technology genetically ablate specifically central nervous system (CNS). Mice with CNS-specific mediated by nestin-Cre showed increased anxiety-like behavior, revealing crucial role complex behavioral phenotype. Our KO also defined regulating VMH expression target genes implicated anxiety energy homeostasis. Therefore, this review will focus on our recent defining functional linked
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