Stem cell transplantation as rescue therapy for refractory Crohn's disease: a sytematic review.

摘要: Background Crohn's disease is a chronic relapsing- remitting affection. It has strong immunologic component which represent the target of standard therapies including immunosppressants and biological therapies. However, many patients remain refracory or intolerant to these Aim The aim this review determine effects stem cell transplantation in with refractory disease. Methods Systematic observational studies, clinical trials case reports that focused on effectiveness safety Results Hematopoietic seems be efficient maintaining endoscopic remission current it been associated high morbidity mortality due chemotherapy. Mesenchymal could induce fistulising Crohns no severe side effects. Its impact luminal still controversial. Conclusion Stem hold promising because related chemotherapy, hematopoietic should used as last resort control Effectiveness mesenchymal yet proven.