Cibles sérotoninergiques et non sérotoninergiques des ISRS : approches pharmacologique et génétique in vivo chez la souris
作者： Thanh Hai Nguyen
DOI:
关键词: Molecular biology 、 Frontal cortex 、 Intracerebral microdialysis 、 Chemistry
摘要: Les inhibiteurs selectifs de recapture la serotonine (5-HT) (ISRS) bloquent directement le transporteur 5-HT (SERT) et stimulent indirectement multiples auto- heterorecepteurs5-HT par l’augmentation concentration extracellulaire dans fente synaptique. Cependant, role des differents recepteurs ainsi que leur interaction les effets therapeutiques ISRS restent mal connus. Nous avons tente identifier a l'aide tests neurochimiques (microdialyse intracerebrale in vivo) electrophysiologiques en utilisant une approche pharmacologique (utilisation escitalopram, ligands 5-HT1A/2A) genetique souris knock-out [KO] SERT, 5-HT1A ou 5-HT2A). etudes revelent auto-(1A) hetero-(2A) recepteursagissent concert pour maintenir influence inhibitrice sur systeme serotoninergique, particulier, reponse au escitalopram : l'absence d'un recepteur est compensee regulation l'autre. Enfin, KO SERT constituent un nouveau modele tester mecanisme du concentrations noradrenaline (NA).
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