Nigrostriatal lesion alters neurophysiological responses to selective and nonselective D-1 and D-2 dopamine agonists in rat globus pallidus.

摘要: The effects of the selective D-1 dopamine agonist SKF 38893, D-2 quinpirole, and nonselective D-1/D-2 apomorphine on spontaneous activity globus pallidus neurons were compared in normal control rats with unilateral 6-hydroxydopamine induced lesions nigrostriatal pathway. In control, unlesioned rats, 38393 (0.4 10 mg/kg, i.v.) caused no significant net change neurons, although some individual cells showed increases decreases discharge rates following mg/kg administration. animals lesions, greater reates a larger percentage pallidal recorded ipsilateral side than animals. These rate changes effectively reversed by antagonist SCH 23390, but not YM-09151–2. Quinpirole (0.3 produced modest significantly lesioned YM-09151–2, quinpirole's As previously reported, large rats. contrast, markedly increased, others decreased, unaffected spiroperidol partially to fully these changes. summary, apomorphine's neurophysiological profile appears be an exaggeration degree observed after administration is consistent results from other studies that have indicated synergistic interaction between triggered stimulation two receptor subtypes can occur animals, as However, further show denervated receptors or processes they mediate are altered so longer requirement seen controls for concurrent complementary subtype expression effects.