Effect of Adjuvant Tamoxifen on the Endometrium in Women With Breast Cancer: A Prospective Study Using Office Endometrial Biopsy
作者： R.R. Barakat , T.A. Gilewski , L. Almadrones , P.E. Saigo , E. Venkatraman
DOI: 10.1200/JCO.2000.18.20.3459
关键词: Prospective cohort study 、 Breast cancer 、 Gynecology 、 Antiestrogen 、 Axillary lymph nodes 、 Mammary gland 、 Tamoxifen 、 Internal medicine 、 Endometrial biopsy 、 Biopsy 、 Medicine
摘要: PURPOSE: To determine the frequency of developing abnormal pathologic changes in endometria tamoxifen-treated women. characterize type involved. PATIENTS AND METHODS: Between October 1991 and September 1998, 159 patients initiating tamoxifen therapy for breast cancer confined to axillary lymph nodes were entered a prospective study. In this study, office endometrial biopsies (EMBs) obtained during initiation at 6-month intervals 2-year period. Three subsequent annual EMBs recorded each patient, amounting 5-year surveillance. RESULTS: One hundred fifty-nine with median age 50 years onto Patients assessable if performed least 1 year after treatment. Nine (5.7%) considered protocol violations. The remaining 111 underwent total 635 (mean, 5.8 EMBs), surveillance time 36 mo...
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