Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

摘要: Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought identify pathways in GWAS data from over 60,000 participants Psychiatric Genomics Consortium. developed an analysis framework rank requires only summary statistics. combined this score across find common three adult disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed strongest association, we also found statistically significant evidence for immune neuronal signaling postsynaptic density. Our study indicates risk variants aggregate particular frequently shared between disorders. results confirm known suggest several novel insights into etiology