Synthesis of (E,E)-Dienones and (E,E)-Dienals via Palladium-Catalyzed γ,δ-Dehydrogenation of Enones and Enals.
作者： Gao-Fei Pan , Xing-Long Zhang , Xue-Qing Zhu , Rui-Li Guo , Yong-Qiang Wang
DOI: 10.1016/J.ISCI.2019.09.027
关键词: Conjugated system 、 Combinatorial chemistry 、 Organic synthesis 、 Catalysis 、 Chemistry 、 Palladium 、 Dehydrogenation 、 Molecular oxygen 、 Functional group 、 Reaction conditions
摘要: Summary A new strategy for the synthesis of conjugated (E,E)-dienones and (E,E)-dienals via a palladium-catalyzed aerobic γ,δ-dehydrogenation enones enals has been developed. The method can be employed in direct efficient various (E,E)-dienals, including non-substituted α-, β-, γ- and/or δ-substituted (E,E)-dienals. protocol is featured by ready accessibility elaboration starting materials, good functional group compatibility, mild reaction conditions. Furthermore, complete E,E-stereoselectivity uses molecular oxygen as sole clean oxidant.
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